Translocator Protein Deficiency Promotes Splenomegaly with Extramedullary Hematopoiesis after Sepsis
RNA-seq (gene expression) · mouse · 24 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 24 samples: 8 × WT+Sham vs 8 × WT+CLP vs 8 × TSPOKO+CLPGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Translocator Protein Deficiency Promotes Splenomegaly with Extramedullary Hematopoiesis after SepsisShock (Augusta, Ga.) · 2026
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE329160_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1458060 and SRA study SRP695159. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 24 samples.
How we read this: 3 replicated groups read from 24 sample titles; they account for 24 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9698431 WT+Sham1 WT+Sham
- GSM9698432 WT+Sham2 WT+Sham
- GSM9698433 WT+Sham3 WT+Sham
- GSM9698434 WT+Sham4 WT+Sham
- GSM9698435 WT+Sham5 WT+Sham
- GSM9698436 WT+Sham6 WT+Sham
- GSM9698437 WT+Sham7 WT+Sham
- GSM9698438 WT+Sham8 WT+Sham
- GSM9698439 WT+CLP1 WT+CLP
- GSM9698440 WT+CLP2 WT+CLP
- GSM9698441 WT+CLP3 WT+CLP
- GSM9698442 WT+CLP4 WT+CLP
- GSM9698443 WT+CLP5 WT+CLP
- GSM9698444 WT+CLP6 WT+CLP
- GSM9698445 WT+CLP7 WT+CLP
- GSM9698446 WT+CLP8 WT+CLP
- GSM9698447 TSPOKO+CLP1 TSPOKO+CLP
- GSM9698448 TSPOKO+CLP2 TSPOKO+CLP
- GSM9698449 TSPOKO+CLP3 TSPOKO+CLP
- GSM9698450 TSPOKO+CLP4 TSPOKO+CLP
- GSM9698451 TSPOKO+CLP5 TSPOKO+CLP
- GSM9698452 TSPOKO+CLP6 TSPOKO+CLP
- GSM9698453 TSPOKO+CLP7 TSPOKO+CLP
- GSM9698454 TSPOKO+CLP8 TSPOKO+CLP
- GSE260765 Context-Dependent Modification of PFKFB3 in Hematopoietic Stem Cells Promotes Anaerobic Glycolysis and Ensures Stress Hematopoiesis 21 samples shares hematopoiesis, promotes
- GSE218778 Extramedullary hematopoiesis and immune training drive systemic inflammation and associated organ damage in Systemic Lupus Erythematosus (RNA-seq) 12 samples shares extramedullary, hematopoiesis
- GSE215455 JAK2V617F-dependent clonal hematopoiesis drives vascular resident macrophages toward a pathogenic phenotype and promotes dissecting aortic aneurysm 10 samples shares hematopoiesis, promotes
- GSE228098 Hepatic loss-of-function phenotype in the peripheral benzodiazepine receptor (PBR) also known as the mitochondrial translocator protein (TSPO), knockout mice (TSPO-/- mice). 7 samples shares translocator, protein
- GSE306040 B12 promotes an inflammatory microenvironment, gut dysbiosis, and potentiates myeloid-biased clonal hematopoiesis 6 samples shares hematopoiesis, promotes
- GSE316282 S-adenosylhomocysteine hydrolase deficiency exacerbates clonal 1 hematopoiesis and atherosclerosis via epigenetic regulation of inflammation 6 samples shares hematopoiesis, deficiency
- GSE248598 Deficiency in peroxisomes underlies failures in neonatal hepatic immune cell hematopoiesis and antigen presentation in a severe Zellweger disease model 3 samples shares hematopoiesis, deficiency
- GSE306448 Milk osteopontin protects against infant bronchiolitis by enhancing microbiome-mediated extramedullary DC hematopoiesis 32 samples shares extramedullary, hematopoiesis
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.