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Transcriptomic of Visceral Adipose Tissue in HFD-induced obesity: evaluation of Resveratrol

GSE329568 Mus musculus Expression profiling by high throughput sequencing 5 samples Submitted 2026/05/04 Platform GPL24247
Summary
Visceral adipose tissue (VAT) expansion during the development of obesity is a hallmark of metabolic syndrome, characterized by hypoxia, oxidative stress, and a shift toward a pro-inflammatory secretome. This series examines the transcriptomic profile of VAT in male C57BL/6 mice subjected to long-term obesity induced by a high-fat diet (HFD, 60% of kcal from fat). To investigate new therapeutic avenues, we evaluated the impact of daily resveratrol administration (2.25 mg/kg) for 28 days, beginning at week 16 of life (8 weeks on the HFD diet). Using a transcriptomic approach (RNA-seq), we mapped the expression changes associated with the transition from healthy to dysfunctional adipose tissue. This study provides a detailed molecular resource for understanding how obesity-induced adipocyte stress can be attenuated by natural bioactives.
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Direct links to NCBI, no account and no request form: the whole study as GSE329568_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 5 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1459690 and SRA study SRP696203. Searching any of these in the dataset finder brings you back here.

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