Platelet-derived S100A9 contributes to Endotheliopathy in Alcohol-Associated Hepatitis
RNA-seq (gene expression) · human · 15 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 15 samples: 8 × Inpatient AH vs 7 × Healthy DonoGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE333389_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1471019 and SRA study SRP704026. Searching any of these in the dataset finder brings you back here.
Supports a case/control comparison: 8 samples read as cases, 7 as controls.
How we read this: 2 replicated groups read from 15 sample titles; they account for 15 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9761990 Inpatient AH 1 Inpatient AH
- GSM9761991 Inpatient AH 2 Inpatient AH
- GSM9761992 Inpatient AH 3 Inpatient AH
- GSM9761993 Inpatient AH 19 Inpatient AH
- GSM9761994 Inpatient AH 28 Inpatient AH
- GSM9761995 Inpatient AH 33 Inpatient AH
- GSM9761996 Inpatient AH 51 Inpatient AH
- GSM9761997 Inpatient AH52 Inpatient AH
- GSM9761998 Healthy Donor 1 Healthy Dono
- GSM9761999 Healthy Donor 2 Healthy Dono
- GSM9762000 Healthy Donor 3 Healthy Dono
- GSM9762001 Healthy Donor 4 Healthy Dono
- GSM9762002 Healthy Donor 35 Healthy Dono
- GSM9762003 Healthy Donor 32 Healthy Dono
- GSM9762004 Healthy Donor 31 Healthy Dono
- GSE270043 Alcohol-associated hepatitis induces hepatocyte senescence which is reduced following disease resolution 73 samples shares alcohol-associated, hepatitis
- GSE270042 Alcohol-associated hepatitis induces hepatocyte senescence which is reduced following disease resolution II 65 samples shares alcohol-associated, hepatitis
- GSE255772 IL-8+ neutrophils drive inexorable inflammation in severe alcohol-associated hepatitis [scRNA-seq] 13 samples shares alcohol-associated, hepatitis
- GSE255379 Interleukin-6 Trans Signaling and STAT-3 Activation Promote Neutrophilic Inflammation in Alcohol-Associated Hepatitis 9 samples shares alcohol-associated, hepatitis
- GSE269566 Alcohol-associated hepatitis induces hepatocyte senescence which is reduced following disease resolution I 8 samples shares alcohol-associated, hepatitis
- GSE215929 Candida albicans-specific Th17 cell-mediated response contributes to alcohol-associated liver disease [bulk TCR-seq] 8 samples shares alcohol-associated, contributes
- GSE215930 Candida albicans-specific Th17 cell-mediated response contributes to alcohol-associated liver disease [scRNA & scTCR-seq] 4 samples shares alcohol-associated, contributes
- GSE283851 S100A9 Overexpression Drives Chemoresistance and Poor Prognosis in AML with Adavivint as a Targeted Therapeutic 18 samples shares s100a9
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.