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Alcohol-associated hepatitis induces hepatocyte senescence which is reduced following disease resolution I

GSE269566 Homo sapiens Expression profiling by high throughput sequencing 8 samples Submitted 2025/03/28 Platform GPL30173
Summary
Alcohol-associated hepatitis (AH) is an acute form of alcohol-related liver disease (ArLD) with high mortality rate. AH is histologically characterised by cellular processes including steatosis, inflammation and cell death. Apoptosis is the most studied form of cell death in AH; however, the role of cellular senescence, another response to cellular injury, in AH is unknown. Here we aim to explore the mechanisms of ArLD pathophysiology and define the role of senescence in AH.
Published in
Longitudinal paired liver biopsies and transcriptome profiling in alcohol-associated hepatitis reveal dynamic changes in cellular senescence
Rodrigo-Torres D, Kilpatrick AM, Ferreira-Gonzalez S et al. · Gut 2025 · PMID 40122595 · doi:10.1136/gutjnl-2024-334094
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Direct links to NCBI, no account and no request form: the whole study as GSE269566_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 8 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1122531 and SRA study SRP513148. Searching any of these in the dataset finder brings you back here.

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