Depletion of endothelial KLF4 drives age-related neurovascular dysfunction and neuropsychiatric impairment [ATAC-seq]
ChIP-seq / ATAC-seq (genome binding and open chromatin) · mouse · 9 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Mus musculus (mouse)
- Samples
- 9 samples: 3 × Young Brain ECK4KO vs 2 × Young Brain CdH5Cre vs 2 × Old Brain ECk4KO vs 2 × Old Brain CdH5 CREGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Endothelial KLF4 depletion drives age-related neurovascular dysfunction and neuropsychiatric impairmentProceedings of the National Academy of Sciences of the United States of America · 2026
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE333395_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1471023 and SRA study SRP704030. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 9 samples.
How we read this: 4 replicated groups read from 9 sample titles; they account for 9 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9762045 Young Brain ECK4KO replicate 1 Young Brain ECK4KO
- GSM9762046 Young Brain ECK4KO replicate 2 Young Brain ECK4KO
- GSM9762047 Young Brain ECK4KO replicate 3 Young Brain ECK4KO
- GSM9762048 Young Brain CdH5Cre replicate 1 Young Brain CdH5Cre
- GSM9762049 Young Brain CdH5Cre replicate 2 Young Brain CdH5Cre
- GSM9762050 Old Brain ECk4KO replicate 1 Old Brain ECk4KO
- GSM9762051 Old Brain ECk4KO replicate 2 Old Brain ECk4KO
- GSM9762053 Old Brain CdH5 CRE replicate 1 Old Brain CdH5 CRE
- GSM9762055 Old Brain CdH5 CRE replicate 2 Old Brain CdH5 CRE
- GSE325187 Senescent Endothelial Cells in Cerebral Microcirculation Are Key Drivers of Age-Related Blood-Brain Barrier Disruption, Microvascular Rarefaction, and Neurovascular Coupling Impairment in Mice 20 samples shares neurovascular, endothelial, age-related, impairment
- GSE296698 Vascular Cell Senescence and Age-Related Endothelial Dysfunction: The Role of the Senescence-Associated Secretory Phenotype and CXCL12 15 samples shares endothelial, age-related, dysfunction
- GSE316502 Transcriptomic Profiling of the Sex-linked Biological Pathways of Severe Pulmonary Arterial Hypertension associated with Endothelial Cell Caveolin-1 Depletion and Chronic Hypoxia 35 samples shares endothelial, depletion
- GSE285475 Endothelial transcription factor EB protects against doxorubicin-induced endothelial toxicity and cardiac dysfunction 18 samples shares endothelial, dysfunction
- GSE294816 p16-expressing microglia and endothelial cells promote tauopathy and neurovascular abnormalities in PS19 mice 16 samples shares neurovascular, endothelial
- GSE296709 Effect of depletion of Endothelial Cell STING in response to pressure overload induced heart failure 15 samples shares endothelial, depletion
- GSE294795 Hypertension-Induced Neurovascular and Cognitive Dysfunction at Single-Cell Resolution 12 samples shares neurovascular, dysfunction
- GSE289751 Resolution of inflammation in imprinted fibroblast-like synoviocytes establishes a transcriptomic signature that promotes endothelial cell dysfunction. 12 samples shares endothelial, dysfunction
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.