GEO series
Depletion of endothelial KLF4 drives age-related neurovascular dysfunction and neuropsychiatric impairment [ATAC-seq]
GSE333395
Mus musculus
Genome binding/occupancy profiling by high throughput sequencing
9 samples
2026/05/28
GPL24247
Summary
Omni-ATAC sequencing was performed on purified brain endothelial nuclei from young and aged endothelial-specific Klf4 knockout (EC-K4KO) and WT Cre mice to investigate chromatin accessibility changes associated with endothelial aging and neurovascular dysfunction. Endothelial KLF4 loss induced chromatin remodeling enriched for inflammatory, stress-response, and senescence-associated pathways.
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Paper (PMID 42313933) ↗
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