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Depletion of endothelial KLF4 drives age-related neurovascular dysfunction and neuropsychiatric impairment [ChIP-Seq]

GSE333397 Mus musculus Genome binding/occupancy profiling by high throughput sequencing 4 samples Submitted 2026/05/28 Platform GPL24247
Summary
Brain aging is associated with neurovascular uncoupling, blood-brain barrier (BBB) dysfunction, neuroinflammation, and cognitive decline. Brain endothelial cells are essential for maintaining BBB integrity and neurovascular homeostasis and are enriched for the transcription factor Krüppel-like factor 4 (KLF4). Because endothelial KLF4 expression declines with aging, we investigated whether endothelial KLF4 depletion contributes to age-associated neurovascular dysfunction and neuropsychiatric impairment.
Published in
Endothelial KLF4 depletion drives age-related neurovascular dysfunction and neuropsychiatric impairment
Dhar M, Vázquez-Rosa E, Chaubey K et al. · Proceedings of the National Academy of Sciences of the United States of America 2026 · PMID 42313933 · doi:10.1073/pnas.2426990123
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Direct links to NCBI, no account and no request form: the whole study as GSE333397_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 4 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1471016 and SRA study SRP704043. Searching any of these in the dataset finder brings you back here.

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