Targeting YAP1 Attenuates Persistent Oxidative Stress-Driven Tubular Cell Senescence
RNA-seq (gene expression) · human · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 12 samples: 4 × ShNC vs 4 × H2O2 vs 4 × YHGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Targeting YAP1-Mediated Tubular Cell Senescence to Attenuate Maladaptive Repair and Fibrotic Transition After Acute Kidney InjuryFASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE333763_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1467889 and SRA study SRP701907. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 3 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9772339 ShNC-1 ShNC
- GSM9772340 ShNC-2 ShNC
- GSM9772341 ShNC-3 ShNC
- GSM9772342 ShNC-4 ShNC
- GSM9772343 H2O2-1 H2O2
- GSM9772344 H2O2-2 H2O2
- GSM9772345 H2O2-3 H2O2
- GSM9772346 H2O2-4 H2O2
- GSM9772347 YH-1 YH
- GSM9772348 YH-2 YH
- GSM9772349 YH-3 YH
- GSM9772350 YH-4 YH
- GSE328981 Quantum Molecular Resonance attenuates an oxidative stress-induced chimeric transcriptome program in human retinal pigment epithelial cells, preserving RNA structural fidelity 108 samples shares attenuates, oxidative
- GSE301872 Therapy-persistent leukemia is selectively vulnerable to SLC23A1 restoration via targeting KHSRP (PDX samples from different disease statuses) 15 samples shares persistent, targeting
- GSE320527 Targeting Mannosylation of Nicastrin N-glycans Attenuates γ-Secretase Activity and Notch-dependent Leukemia Progression 12 samples shares attenuates, targeting
- GSE310264 Kaempferol Attenuates Spaceflight-associated Knee Cartilage Degeneration by Targeting NOX4-Mediated Mitochondrial Dysfunction 9 samples shares attenuates, targeting
- GSE301870 Therapy-persistent leukemia is selectively vulnerable to SLC23A1 restoration via targeting KHSRP (KHSRP knockdown in CAL-1 cells) 9 samples shares persistent, targeting
- GSE337663 Therapy-persistent leukemia is selectively vulnerable to SLC23A1 restoration via targeting KHSRP (AML patient samples) 8 samples shares persistent, targeting
- GSE333617 Targeting JAK1/3-STAT1 signaling attenuates cytotoxic T lymphocytes activation for the treatment in Stevens-Johnson syndrome and toxic epidermal necrolysis 26 samples shares attenuates, targeting
- GSE259388 YAP1/TAZ knockdown in melanoma 54 samples shares yap1
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.