GEO series
Human metapneumovirus and mumps virus alter the m6A landscapes in THP-1-derived immature dendritic cells
GSE333903
Homo sapiens
Expression profiling by high throughput sequencing; Other
12 samples
2026/07/10
GPL29480
Summary
N6-methyladenosine (m6A) is a widespread mRNA modification that regulates RNA metabolism and influences virus-induced immune responses. We performed MeRIP-seq to profile m6A landscapes in THP-1-derived immature dendritic cells (THP-iDCs) before and after infection with Human metapneumovirus (hMPV, NL/00/1) or mumps virus (MuV, JL2). Integration of m6A modifications on key innate immune transcripts with transcriptomic data, together with m6A levels on cellular and viral RNA, revealed a dual role of m6A in viral replication and host immune regulation. These datasets provide a resource for exploring epitranscriptomic regulation during hMPV and MuV infection.
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