Cardiotoxin from Naja atra Activates the NLRP3/Caspase-1/GSDMD Pyroptosis Pathway to Induce Skin Tissue Injury
RNA-seq (gene expression) · mouse · 16 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 16 samples: 12 × C vs 4 × NCGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE334138_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1473889 and SRA study SRP706193. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 16 samples.
How we read this: 2 replicated groups read from 16 sample titles; they account for 16 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9781789 C121 C
- GSM9781790 C122 C
- GSM9781791 C123 C
- GSM9781792 C124 C
- GSM9781793 C241 C
- GSM9781794 C242 C
- GSM9781795 C243 C
- GSM9781796 C244 C
- GSM9781797 C61 C
- GSM9781798 C62 C
- GSM9781799 C63 C
- GSM9781800 C64 C
- GSM9781801 NC1 NC
- GSM9781802 NC2 NC
- GSM9781803 NC3 NC
- GSM9781804 NC4 NC
- GSE235016 RNA-seq revealed the anti-pyroptotic effect of suramin by suppressing NLRP3/caspase-1/GSDMD pathway in LPS-induced MH-S alveolar macrophages 9 samples shares caspase-1, nlrp3, gsdmd, induce
- GSE282594 Pseudorabies virus induces Natural killer cell depletion by GSDMD-mediated inflammation and pyroptosis to promote infection and lung injury 8 samples shares gsdmd, pyroptosis, induce, injury
- GSE245988 Vascular endothelial S1PR2 aggravates cardiac ischemia/reperfusion injury through triggering mitochondrial dysfunctions and endothelial pyroptosis via RHO/ROCK1/DRP1/NLRP3 pathway [endothelial cells] 6 samples shares nlrp3, pyroptosis, injury
- GSE273921 NLRP3 Amplifies Inflammatory Signaling in Acute Lung Injury Induced by Cell Wall Extract of Gram-positive Bacteria 6 samples shares nlrp3, induce, injury
- GSE245987 Vascular endothelial S1PR2 aggravates cardiac ischemia/reperfusion injury through triggering mitochondrial dysfunctions and endothelial pyroptosis via RHO/ROCK1/DRP1/NLRP3 pathway [heart] 4 samples shares nlrp3, pyroptosis, injury
- GSE234844 STING Signaling Contributes to Celastrol-induced Pyroptosis of Female Germline Stem Cells by Upregulating NLRP3 4 samples shares nlrp3, pyroptosis, induce
- GSE245446 The collaboration of GSDMD and GSDME in folic acid (FA)-induced renal injury 2 samples shares gsdmd, induce, injury
- GSE297859 Caspases 3 and 7 restrict intestinal inflammation by regulating stem cell function and gsdmd-mediated pyroptosis 42 samples shares gsdmd, pyroptosis
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.