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NLRP3 Amplifies Inflammatory Signaling in Acute Lung Injury Induced by Cell Wall Extract of Gram-positive Bacteria

GSE273921 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2024/11/10 Platform GPL24247
Summary
Transcriptomic analysis suggested that LCWE and LPS both induce Toll/NF-kB and TNF signalings in ALI, and LCWE additionally promotes T cell differentiation.We established a murine model of ALI-induced by LCWE. TLR2 receptors are activated by LCWE and transmitted through the MYD88 signaling pathway, activating NF-kappaB which leads to the production of IL1b and activation of TNFR and NLRP3 signaling pathways.
Published in
NLRP3 promotes inflammatory signaling and IL-1β cleavage in acute lung injury caused by cell wall extract of Lactobacillus casei
Gu L, Zhu J, Nie Q et al. · Communications biology 2025 · PMID 39774843 · doi:10.1038/s42003-025-07462-9
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Also filed as BioProject PRJNA1144104 and SRA study SRP524105. Searching any of these in the dataset finder brings you back here.

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