C1QBP expression and function in acute myeloid leukaemia.

Acute myeloid leukemia (AML) is a lethal hematological malignancy that originates from unlimited proliferation of immature progenitors characterized by medullary and extramedullary invasion, with a 5-year overall survival (OS) rate of <30% with chemotherapy. Infiltration of bone marrow (BM) malignant leukemia cells into tissues other than the BM to form an extramedullary mass, referred to as extramedullary infiltration (EMI), is a common concomitant symptom of AML, with an incidence at initial diagnosis ranging from 2.5% to 30.5%,4-10 to even 65% if diagnosed by positron emission tomography/ computed tomography. Our privios study have identified the most featured macrophage-like C1Q+ population associated with EMI and adverse outcome and confirmed its unique function in migration. Here, we want to know the expression and function of C1QBP as the surface globular C1Q receptor in patients with AML who experience EMI.