GEO series
Effects of norepinephrine(NE) and dexamethasone(DEX) exposure on signaling pathways in ciliary body cells
GSE335628
Homo sapiens
Expression profiling by high throughput sequencing
14 samples
2026/06/23
GPL28038
Summary
Aqueous humor production by the ciliary body is regulated in part by hormonal cues, including norepinephrine (NE) and dexamethasone (DEX), and its circadian variation is thought to reflect rhythmic changes in these signals. However, the transcriptional programs and molecular pathways through which NE and DEX influence human non-pigmented ciliary epithelial cells remain incompletely defined. In this study, we performed RNA-seq analysis of human non-pigmented ciliary epithelial cells exposed to NE or DEX for 1 or 2 hours, with vehicle-treated cells as controls, to identify stimulus-responsive genes and pathways associated with ciliary body function and aqueous humor production.
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