Chromatin topology dynamics of dexamethasone-treated trabecular meshwork identifies 78 causal genes for intraocular pressure and primary open angle glaucoma [RNA-seq]
RNA-seq (gene expression) · human · 21 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 21 samples: 6 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Chromatin dynamics identifies 78 genes at loci associated with elevated intraocular pressure and primary open-angle glaucomabioRxiv : the preprint server for biology · 2026
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE301517_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1285385 and SRA study SRP597899. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 17 samples.
How we read this: 6 replicated groups read from 21 sample titles; they account for 17 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9084578 Resource Total RNA TM62, Rep1 Resource Total RNA TM62,
- GSM9084579 Resource Total RNA TM62, Rep2 Resource Total RNA TM62,
- GSM9084580 Resource Total RNA TM62, Rep3 Resource Total RNA TM62,
- GSM9084581 Resource Total RNA TM71 Rep1
- GSM9084582 Resource Total RNA TM71, Rep2
- GSM9084583 Resource Total RNA TM83, Rep1 Resource Total RNA TM83,
- GSM9084584 Resource Total RNA TM83, Rep2 Resource Total RNA TM83,
- GSM9084585 Control Total RNA TM62, Rep1 Control Total RNA TM62,
- GSM9084586 Control Total RNA TM62, Rep2 Control Total RNA TM62,
- GSM9084587 Control Total RNA TM62, Rep3 Control Total RNA TM62,
- GSM9084588 Control Total RNA TM62, Rep4 Control Total RNA TM62,
- GSM9084589 Dex Total RNA TM62, Rep1 Dex Total RNA TM62,
- GSM9084590 Dex Total RNA TM62, Rep2 Dex Total RNA TM62,
- GSM9084591 Dex Total RNA TM62, Rep3 Dex Total RNA TM62,
- GSM9084592 Dex Total RNA TM62, Rep4 Dex Total RNA TM62,
- GSM9084593 Control Total RNA TM70, Rep1 Control Total RNA TM70,
- GSM9084594 Control Total RNA TM70, Rep2 Control Total RNA TM70,
- GSM9084595 Dex Total RNA TM70, Rep1 Dex Total RNA TM70,
- GSM9084596 Dex Total RNA TM70, Rep2 Dex Total RNA TM70,
- GSM9084597 Control Total RNA TM72, Rep1
- GSM9084598 Dex Total RNA TM72, Rep1
- GSE301525 Chromatin topology dynamics of dexamethasone-treated trabecular meshwork identifies 78 causal genes for intraocular pressure and primary open angle glaucoma 131 samples shares dexamethasone-treated, intraocular, trabecular, identifies, chromatin, topology, dynamics, meshwork
- GSE301512 Chromatin topology dynamics of dexamethasone-treated trabecular meshwork identifies 78 causal genes for intraocular pressure and primary open angle glaucoma [CUT&Run] 30 samples shares dexamethasone-treated, intraocular, trabecular, identifies, chromatin, topology, dynamics, meshwork
- GSE301516 Chromatin topology dynamics of dexamethasone-treated trabecular meshwork identifies 78 causal genes for intraocular pressure and primary open angle glaucoma [ATAC] 12 samples shares dexamethasone-treated, intraocular, trabecular, identifies, chromatin, topology, dynamics, meshwork
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Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.