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Tailored FcγR blockade enhances immune checkpoint therapy and overcomes resistance

GSE335831 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2026/07/29 Platform GPL24247
Summary
We conducted single-cell RNA sequencing using the 10x Genomics Chromium Next-GEM Flex protocol to investigate the mechanism of action behind the improved therapeutic efficacy of anti-CTLA4 seen when combined with FcgrII blockade. Our goal was to understand the mechanism of action of the combination of anti-CTLA4 and anti-FcgrII in comparison to anti-CTLA4 single treatment. These studies provide new insights and role of FcgrII blockade as therapeutic target in cancer.
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Direct links to NCBI, no account and no request form: the whole study as GSE335831_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 4 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1479667 and SRA study SRP710621. Searching any of these in the dataset finder brings you back here.

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