GEO series
Myl1+ adipose progenitor cells (APCs) support brown adipose tissue (BAT) maintenance in adult mice
GSE336258
Mus musculus
Expression profiling by high throughput sequencing
8 samples
2026/06/24
GPL24247
Summary
The ontogeny of brown adipose tissue (BAT) begins during embryogenesis and continues into the postnatal period and throughout adulthood. Distinct populations of adipose progenitor cells (APCs) have been identified to support BAT development and thermogenesis; however, the division of labor and temporal relationship between different APCs, particularly during adulthood and aging, remain undetermined. Using integrative single-cell analysis and lineage tracing, we identified a distinct population of Myl1-expressing cells that emerge in an age-dependent manner and function as committed BAT progenitors in adult and middle-aged mice. The blockade of Myl1+ APC differentiation leads to BAT paucity and impaired glucose metabolism in adult mice. Collectively, our results support a progenitor switching model in which distinct APC populations control sequential brown adipogenesis and shape BAT heterogeneity.
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