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Dysregulated thymus-ovary axis promotes virtual memory T cell polarization to aggravate PCOS pathology [scRNAseq-mouse]

GSE336822 Mus musculus Expression profiling by high throughput sequencing; Other 4 samples Submitted 2026/07/03 Platform GPL24247
Summary
Polycystic ovary syndrome (PCOS) is characterized by androgen excess, ovarian dysfunction and polycystic ovarian morphology and is classically considered as a disorder of the hypothalamic-pituitary-gonadal (HPG) axis. However, whether organs beyond the reproductive endocrine axis contribute to PCOS pathogenesis remains elusive. Herein, we identified a functional thymus-ovary axis involved in PCOS development.
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Also filed as BioProject PRJNA1483414 and SRA study SRP713394. Searching any of these in the dataset finder brings you back here.

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