GEO series
Effect of peripheral kappa-opioid receptor agonists on murine T cells
GSE336897
Mus musculus
Expression profiling by high throughput sequencing
24 samples
2026/07/03
GPL34290
Summary
This study investigated the transcriptional responses of murine T cell subsets to treatment with novel peripherally restricted, perhydroquinoxaline-derived kappa opioid receptor (KOR) agonists. We sorted and polarized primary murine CD4+ and CD8+ T cells towards Th1, Th17, Treg and CD8+ T cells and stimulated them with novel KOR agonists or vehicle control (DMSO). RNA sequencing was performed to assess gene expression changes associated with KOR activation across distinct T cell subsets.
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