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Transcriptome profiling of ARHGAP29-depleted human embryonic palatal mesenchymal cells

GSE337334 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2026/07/03 Platform GPL24676
Summary
ARHGAP29 is implicated in nonsyndromic cleft lip with or without cleft palate, but its role in human palatal mesenchymal cells remains incompletely understood. Human embryonic palatal mesenchymal (HEPM) cells were transfected with ARHGAP29-targeting siRNA or a non-targeting negative-control siRNA. Total RNA sequencing was performed for three independent biological replicates per group. The study was designed to identify transcriptional changes associated with ARHGAP29 depletion. Differential expression and functional enrichment analyses indicated changes in developmental and stress-responsive gene programs, including p53- and Notch-related pathways.
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Also filed as BioProject PRJNA1484881 and SRA study SRP714606. Searching any of these in the dataset finder brings you back here.

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