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RASA3 inhibits Tc1 differentiation and attenuates anti-bacteria immunity by restricting the HCK kinase

GSE337937 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2026/07/09 Platform GPL24247
Summary
Type I immunity is defined by IFN-γ secretion, with Tc1 cells as a key subset, yet their intrinsic negative regulators remain unclear. We identified RASA3 as a novel negative regulator of Tc1 cells. T cell-specific deletion of RASA3 enhanced Tc1 differentiation and antibacterial immunity. We further revealed the RASA3–HCK–STAT4 axis in the regulatoin of Tc1 cell generation.
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Also filed as BioProject PRJNA1491702 and SRA study SRP716259. Searching any of these in the dataset finder brings you back here.

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