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RalA-driven CCN3 secretion amplifies inflammatory catabolism to promote temporomandibular joint osteoarthritis

GSE338438 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2026/07/31 Platform GPL24247
Summary
This project investigates the role of RalA in temporomandibular joint osteoarthritis using a mouse MIA-induced TMJOA model and primary mouse temporomandibular joint condylar chondrocytes. Transcriptomic profiling of siNC- and siRalA-transfected chondrocytes was performed to identify RalA-regulated inflammatory and extracellular matrix remodeling pathways. The study identifies CCN3 as a RalA-regulated secreted mediator that amplifies inflammatory cytokine production and cartilage catabolism.
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Direct links to NCBI, no account and no request form: the whole study as GSE338438_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1494478 and SRA study SRP717560. Searching any of these in the dataset finder brings you back here.

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