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DPSCs Transfer Mitochondria via TNTs to Drive Hypoxic Angiogenesis

GSE338573 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2026/07/15 Platform GPL24676
Summary
The dental pulp resides within a rigid dentin chamber with a limited blood supply, creating a hypoxic environment that impedes tissue regeneration. This study identifies intercellular mitochondrial transfer as a critical endogenous rescue mechanism. Human dental pulp stem cells (DPSCs) actively transfer functional mitochondria to green fluorescent protein-expressing human umbilical vein endothelial cells (GFP-ECs) under hypoxic stress. This transfer significantly reduces hypoxia-induced apoptosis, preserves mitochondrial membrane potential, and enhances the angiogenic capacities of recipient ECs. To uncover the molecular mechanisms driving this phenotype, RNA-sequencing (RNA-seq) was performed on mitochondrial-transferred ECs (Mito(+)) and control ECs (Mito(-)) under hypoxia.
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Direct links to NCBI, no account and no request form: the whole study as GSE338573_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1495197 and SRA study SRP717911. Searching any of these in the dataset finder brings you back here.

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