Kv1.3 inhibition alleviates neuropathology via neuroinflammatory and resilience pathways in a mouse model of Aβ pathology
Single-nucleus RNA-seq · mouse · 12 samples
- What it is
- Single-nucleus RNA-seqGene activity measured in individual nuclei (used when whole cells are hard to isolate, for example from frozen tissue). Read from the summary: GEO's own type field only says 'expression profiling by sequencing', so confirm it in the paper.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 12 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Kv1.3 inhibition alleviates neuropathology via neuroinflammatory and resilience pathways in a mouse model of Aβ pathologybioRxiv : the preprint server for biology · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE338689_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Single-cell studies usually ship their counts as 10x files (matrix.mtx, barcodes.tsv, features.tsv), an .h5 file, or an .rds / .h5ad object that Seurat or Scanpy can open. Look for those among the supplementary files.
Also filed as BioProject PRJNA1495533 and SRA study SRP718179. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 12 sample titles: 12 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9879650 Whole brain RNA-seq mouse 2171 Control
- GSM9879651 Whole brain RNA-seq mouse 2172 Control
- GSM9879652 Whole brain RNA-seq mouse 2173 Control
- GSM9879653 Whole brain RNA-seq mouse 2195 PBS
- GSM9879654 Whole brain RNA-seq mouse 2197 PBS
- GSM9879655 Whole brain RNA-seq mouse 2200 PBS
- GSM9879656 Whole brain RNA-seq mouse 2207 ShK-223
- GSM9879657 Whole brain RNA-seq mouse 2208 ShK-223
- GSM9879658 Whole brain RNA-seq mouse 2210 ShK-223
- GSM9879659 Whole brain RNA-seq mouse 2219 PAP-1
- GSM9879660 Whole brain RNA-seq mouse 2222 PAP-1
- GSM9879661 Whole brain RNA-seq mouse 2225 PAP-1
- GSE176506 Synergistic behavioral and neuroinflammatory effects of amyloid neuropathology and sepsis survival in a murine model of Alzheimer’s disease 112 samples shares neuroinflammatory, neuropathology, pathology
- GSE314288 Microglia replacement by ER-Hoxb8 conditionally immortalized macrophages provides insight into Aicardi-Goutières Syndrome neuropathology 92 samples shares neuropathology, pathology
- GSE288803 Proteasome inhibition alleviates proteinuria in Lmx1b knock-in mice with dysfunctional LIM domains 35 samples shares inhibition, alleviates
- GSE325494 Pharmacological inhibition of GLUT1 alleviates fulminant hepatitis by restraining macrophage-induced inflammatory cascades and restoring metabolic homeostasis 9 samples shares inhibition, alleviates
- GSE322775 Coordinated immune activation following KRAS inhibition reveals molecular pathways that potentiate and limit anti-tumor immunity 47 samples shares inhibition
- GSE333494 Hippocampal CA3 Nex+ neuronal TNFR2 alleviates chronic neuropathic pain by sex-dependently engaging opioid and endocannabinoid pathways 26 samples shares alleviates
- GSE294832 Modular neuroinflammatory network discovery from large-scale phenotypic screening in genetically heterogeneous mice [part10] 1000 samples shares neuroinflammatory
- GSE294911 Modular neuroinflammatory network discovery from large-scale phenotypic screening in genetically heterogeneous mice [part14] 1000 samples shares neuroinflammatory
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.