GEO series
Cell culture effects on isolated fibrotic lung CD103+ DCs
GSE338791
Mus musculus
Expression profiling by high throughput sequencing
9 samples
2026/07/20
GPL24247
Summary
The trypophan metabolite kynurenine is a well known AHR ligand and drives inflammatory AHR respones, especially in dendritic cels. Ex vivo studies of dendrtic cells are complicated by the fact that culture conditions do not reproduce complex tissue microenvironments. To study these effects we compared transcriptomes of CD103+ lung DCs isolated from mice with blm-induced fibrosis and compared with DCs that had been cultured in standard culture media for 18h.
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