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RNA-seq transcriptome profiling of HK-2 human renal tubular epithelial cells upon gene knockdown mediated by sgRNA

GSE339245 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2026/07/25 Platform GPL24676
Summary
Renal tubular epithelial injury plays a critical role in the progression of renal interstitial fibrosis. In this study, bulk RNA-seq was performed to investigate transcriptomic alterations in human HK-2 proximal tubular epithelial cells following target gene knockdown via sgRNA. Cells transfected with non-targeting sgRNA were used as negative control. Three biological replicates were included for each group. This dataset provides transcriptome resources to uncover molecular events regulated by the target gene in renal tubular epithelial cells.
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Direct links to NCBI, no account and no request form: the whole study as GSE339245_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1498027 and SRA study SRP719652. Searching any of these in the dataset finder brings you back here.

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