GEO series
Single cell sequencing of APECED patient and Healthy control peripheral blood cells
GSE339254
Homo sapiens
Expression profiling by high throughput sequencing; Other
74 samples
2026/07/28
GPL24676
Summary
10 APECED and 10 Healthy control patients peripheral blood cells isolated for single cell sequencing. scRNA-seq and BCRseq analysis illustrate changes to the composition of the B cell compartment in APECED compared to Healthy control such as a reduction in Naïve B cells and increases to IgM CD27+ CXCR3+ and Class switched atypical B cell subsets with alternative activation (TBX21+ ZEB2+).
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