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Transcriptomic analysis of FTO knockdown in MG63 osteosarcoma cells

GSE341587 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2026/08/01 Platform GPL24676
Summary
Fat mass and obesity-associated protein (FTO), a key N6-methyladenosine (m6A) demethylase, plays critical roles in tumor progression and chemotherapy resistance. However, the downstream transcriptional networks regulated by FTO in osteosarcoma remain incompletely understood. To investigate the molecular mechanisms underlying FTO-mediated osteosarcoma progression and cisplatin sensitivity, we performed transcriptome sequencing (RNA-seq) on MG63 osteosarcoma cells following FTO knockdown. This dataset provides a comprehensive view of the gene expression changes induced by FTO depletion, which may help identify key downstream targets and pathways involved in osteosarcoma pathogenesis and chemoresistance.
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Direct links to NCBI, no account and no request form: the whole study as GSE341587_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1502971 and SRA study SRP721761. Searching any of these in the dataset finder brings you back here.

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