GEO series

The role of micro-RNA genes in papillary thyroid carcinoma

GSE3467 Homo sapiens Expression profiling by array 18 samples Submitted 2005/12/19 Platform GPL570

Summary

We show that numerous miRNAs are transcriptionally up-regulated in papillary thyroid carcinoma (PTC) tumors compared with unaffected thyroid tissue. Among the predicted target genes of the three most upregulated miRNAs (miRs 221, 222 and 146b), only less than 15% showed significant downexpression in transcript level between tumor and unaffected tissue. The KIT gene which is known to be downregulated by miRNAs 221 and 222 displayed dramatic loss of transcript and protein in those tumors that had abundant mir-221, mir-222, and mir-146b transcript. Keywords: Disease state analysis

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Direct links to NCBI, no account and no request form: the whole study as GSE3467_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 18 samples.

Whole study · RAW.tar ↓ Series matrix ↓ All supplementary files ↗

Also filed as BioProject PRJNA93411. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗ Paper (PMID 16365291) ↗

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