GEO series

A genomic storm in critically injured humans

GSE36809 Homo sapiens Expression profiling by array 857 samples Submitted 2012/03/27 Platform GPL570

Summary

Human survival from injury requires an appropriate inflammatory and immune response. We describe the circulating leukocyte transcriptome after severe trauma and show that the severe stress produce a global reprioritization affecting >80% of the cellular functions and pathways, a truly unexpected “genomic storm.” In severe blunt trauma, the early leukocyte genomic response is consistent with simultaneously increased expression of genes involved in the systemic inflammatory, innate immune, and compensatory antiinflammatory responses, as well as in the suppression of genes involved in adaptive immunity. Furthermore, complications like nosocomial infections and organ failure are not associated with any genomic evidence of a second hit and differ only in the magnitude and duration of this genomic reprioritization.

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Direct links to NCBI, no account and no request form: the whole study as GSE36809_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 857 samples.

Whole study · RAW.tar ↓ Series matrix ↓ All supplementary files ↗

Also filed as BioProject PRJNA156919. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗ Paper (PMID 22110166) ↗

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