GEO series

Paternally induced transgenerational inheritance of susceptibility to diabetes in mammals (NimbleGen expression)

GSE43187 Mus musculus (mouse) Expression microarray 12 samples Submitted 2012/12/29 Platform GPL10192

At a glance

Expression microarray · mouse · 12 samples

What it is: Expression microarrayGene activity read on a chip (the older technology that RNA-seq replaced).
Organism: Mus musculus (mouse)
Samples: 12 samples
Data you can get: A processed expression table (series matrix) and the array files, from NCBI.

Summary (written by the submitters)

The global prevalence of type 2 diabetes (T2D) is increasing, and it is contributing to the susceptibility to diabetes and its related epidemic in offspring. Although the impacts of paternal T2D on metabolism of offspring have been well established, the exact molecular and mechanistic basis that mediates these impacts remains largely unclear.

Read the full summary ↓

Here we show that paternal T2D increases the susceptibility to diabetes in offspring through the gametic epigenetic alterations. Paternal T2D led to glucose intolerance and insulin resistance in offspring. Relative to controls, offspring of T2D fathers exhibited altered gene expression patterns in the pancreatic islets, with downregulation of several genes involved in glucose metabolism and insulin signaling pathway. Epigenomic profiling of offspring pancreatic islets revealed numerous changes in cytosine methylation depending on paternal T2D, including reproducible changes in methylation over several insulin signaling genes. Paternal T2D altered overall methylome patterns in sperm, with a large portion of differentially methylated genes overlapped with that of pancreatic islets in offspring. Our study revealed, for the first time, that T2D can be inherited transgenerationally through the mammalian germline by an epigenetic manner.

This dataset

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Download · which file do I need?

Direct links to NCBI, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.

1 · Just have a look

Processed table

The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.

Series matrix ↓

2 · Re-analyse it

Supplementary files

The count tables and other files the authors uploaded. Take only the samples you need.

All supplementary files ↗

3 · The original raw files

Whole study · RAW.tar

Everything the authors deposited as one archive (GSE43187_RAW.tar), including the raw array or instrument files. Can be large; the picker in step 2 takes just the samples you need.

Whole study · RAW.tar ↓

What the files usually look like: For arrays the series matrix is normally the normalised expression table you want; the raw array files (CEL and similar) are in the RAW.tar.

Also filed as BioProject PRJNA184861. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗ Paper (PMID 24449870) ↗

Samples in this study

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+ 12 more — browse all 12 samples with per-sample file links →

Datasets on a similar topic

GSE43239 Paternally induced transgenerational inheritance of susceptibility to diabetes in mammals 16 samples shares transgenerational, susceptibility, inheritance, paternally, diabetes, induced, mammals
GSE25896 Paternally-induced transgenerational environmental reprogramming of metabolic gene expression in mammals (Affymetrix) 8 samples shares transgenerational, paternally, induced, mammals
GSE25899 Paternally-induced transgenerational environmental reprogramming of metabolic gene expression in mammals 42 samples shares transgenerational, paternally, induced, mammals
GSE267720 Transgenerational inheritance of diabetes susceptibility in male offspring with maternal hyperandrogenism 11 samples shares transgenerational, susceptibility, inheritance, diabetes
GSE25897 Paternally-induced transgenerational environmental reprogramming of metabolic gene expression in mammals (small RNA) 8 samples shares transgenerational, paternally, induced, mammals
GSE266255 Transgenerational inheritance of diabetes susceptibility in male offspring with maternal hyperandrogenism [RNA-Seq] 7 samples shares transgenerational, susceptibility, inheritance, diabetes
GSE298401 A Transient Increase in Cardiomyocyte Protein O-GlcNAcylation Enhances Susceptibility to Pressure Overload-Induced Cardiac Remodeling 40 samples shares susceptibility, induced
GSE324816 Amygdala engram ensembles mediate differential susceptibility to short-term negative stress-induced remote depression in adolescent and adult mice 32 samples shares susceptibility, induced

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