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Trans-chromosomal regulation by a novel lincRNA required for adipogenesis that escapes X-chromosome inactivation

GSE45157 Mus musculus; Homo sapiens Expression profiling by high throughput sequencing 21 samples Submitted 2013/06/01 Platform GPL16417Platform GPL11154Platform GPL13112
Summary
Long noncoding RNAs (lncRNAs) have emerged as an important layer of genome regulation with common mechanistic themes including the formation of ribonucleoprotein complexes. Here, we present a novel X-linked lncRNA termed linc-Firre that escapes X-chromosome inactivation and forms trans-chromosomal interactions required for adipogenesis. Linc-Firre is exclusively nuclear and forms punctate expression foci on chromatin near its site of transcription on both X-chromosomes in human and mouse. Both the localization of linc-Firre and the association with the nuclear matrix protein hnRNPU require a conserved repeating RNA domain, R2D2. Collectively, these results reveal a lincRNA that escapes X-chromosome inactivation with a critical role in driving cell fate decisions by trans-chromosomal interactions.
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Also filed as BioProject PRJNA193156 and SRA study SRP019270. Searching any of these in the dataset finder brings you back here.

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