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Alzheimer's Disease Dataset

GSE48350 Homo sapiens (human) Expression microarray 253 samples Submitted 2014/04/21 Platform GPL570
At a glance

Expression microarray · human · 253 samples

What it is
Expression microarrayGene activity read on a chip (the older technology that RNA-seq replaced).
Organism
Homo sapiens (human)
Samples
253 samples: 193 distinct titles, 38 of them repeatedGroups are read from the sample names, not from the paper. Check the list below.
Data you can get
A processed expression table (series matrix) and the array files, from NCBI.
Summary (written by the submitters)
This dataset contains microarray data from normal controls (aged 20-99 yrs) and Alzheimer's disease cases, from 4 brain regions: hippocampus, entorhinal cortex, superior frontal cortex, post-central gyrus. Changes in expression of synaptic and immune related genes were analyzed, investigating age-related changes and AD-related changes, and region-specific patterns of change. These AD cases were processed simultaneously with the control cases (young and aged) included in GSE11882 (GSE11882 dataset contains data exclusively from normal control brains).
This dataset
Open GSE48350 in finder → Find more human microarray datasets →
Download · which file do I need?

Direct links to NCBI, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.

1 · Just have a look

Processed table

The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.

Series matrix ↓
2 · Re-analyse it

Supplementary files

The count tables and other files the authors uploaded. Take only the samples you need.

All supplementary files ↗
3 · The original raw files

Whole study · RAW.tar

Everything the authors deposited as one archive (GSE48350_RAW.tar), including the raw array or instrument files. Can be large; the picker in step 2 takes just the samples you need.

Whole study · RAW.tar ↓

What the files usually look like: For arrays the series matrix is normally the normalised expression table you want; the raw array files (CEL and similar) are in the RAW.tar.

Also filed as BioProject PRJNA209800. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗ Paper (PMID 18832152) ↗
Study design
193 distinct titles, 38 of them repeated
SuperiorFrontalGyrus_female_91yrs_indiv ×4 SuperiorFrontalGyrus_female_74yrs_indiv ×4 post-central gyrus_female_90_AD ×4 superior frontal gyrus_female_90_AD ×4 PostcentralGyrus_female_91yrs_indiv ×3 EntorhinalCortex_female_74yrs_indiv ×3 Hippocampus_female_74yrs_indiv ×3 PostcentralGyrus_female_74yrs_indiv ×3 +30 more

How we read this: Read from 253 sample titles: 193 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.

Samples in this study

+ 213 more — browse all 253 samples with per-sample file links →

Datasets on a similar topic

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