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Replication Stress is a Potent Driver of Functional Decline in Aging in Hematopoietic Stem Cells

GSE48893 Mus musculus Expression profiling by array 15 samples Submitted 2014/07/14 Platform GPL6246
Summary
To understand at the molecular level the differences between old HSCs and young HSCs we have performed genome-wide analyses using Affymetrix Gene ST 1.0 microarrays with FACS purified cell populations. In contrast to other datasets comparing young and old HSCs, we compared both young and old HSCs and GMPs, and subtracted for genes that were also differentially expressed between young and old GMPs using a zero-intercept linear model. This allowed us to identify 913 significantly differentially expressed genes that were specific to old HSCs and segregated into different clusters.
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Also filed as BioProject PRJNA212140. Searching any of these in the dataset finder brings you back here.

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