GEO series

Expression data for Nonalcoholic fatty liver disease patients

GSE49541 Homo sapiens (human) Expression microarray 72 samples Submitted 2013/08/30 Platform GPL570

At a glance

Expression microarray · human · 72 samples

What it is: Expression microarrayGene activity read on a chip (the older technology that RNA-seq replaced).
Organism: Homo sapiens (human)
Samples: 72 samples
Data you can get: A processed expression table (series matrix) and the array files, from NCBI.

Summary (written by the submitters)

Nonalcoholic fatty liver disease represents a spectrum of pathology that ranges from benign steatosis to potentially-progressive steatohepatitis and affects more than 30% of US adults. Advanced NAFLD is associated with increased morbidity and mortality from cirrhosis, primary liver cancer, cardiovascular disease and extrahepatic cancers.

Read the full summary ↓

Accurate identification of patients at risk for advanced NAFLD is challenging. The aims of this study were to define the liver gene expression patterns that distinguish mild from advanced NAFLD and to develop a gene expression profile associated with advanced NAFLD.

This dataset

Open GSE49541 in finder → Find more human microarray datasets →

Download · which file do I need?

Direct links to NCBI, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.

1 · Just have a look

Processed table

The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.

Series matrix ↓

2 · Re-analyse it

Supplementary files

The count tables and other files the authors uploaded. Take only the samples you need.

All supplementary files ↗

3 · The original raw files

Whole study · RAW.tar

Everything the authors deposited as one archive (GSE49541_RAW.tar), including the raw array or instrument files. Can be large; the picker in step 2 takes just the samples you need.

Whole study · RAW.tar ↓

What the files usually look like: For arrays the series matrix is normally the normalised expression table you want; the raw array files (CEL and similar) are in the RAW.tar.

Also filed as BioProject PRJNA214553. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗ Paper (PMID 23913408) ↗

Samples in this study

The sample list for this study is not cached yet. Press Load samples and it will be fetched from NCBI.

+ 72 more — browse all 72 samples with per-sample file links →

Datasets on a similar topic

GSE260666 Differential analysis of gene expression in liver tissues of patients with nonalcoholic fatty liver disease and controls. 16 samples shares nonalcoholic, fatty, liver
GSE130970 Gene expression predicts histological severity and reveals distinct molecular profiles of nonalcoholic fatty liver disease 78 samples shares nonalcoholic, fatty, liver
GSE202379 Single Nuclei RNA-Seq to map progression of non-alcoholic fatty liver disease (NAFLD) in patients II 59 samples shares fatty, liver
GSE135251 TRANSCRIPTOMIC PROFILING ACROSS THE SPECTRUM OF NON-ALCOHOLIC FATTY LIVER DISEASE 216 samples shares fatty, liver
GSE167523 Transcriptome profiling of human non-alcoholic fatty liver disease 98 samples shares fatty, liver
GSE23343 Expression data from human liver with or without type 2 diabetes 17 samples shares liver
GSE281797 Transcriptomic profiles of liver biopsies in obese patients with metabolic dysfunction-associated steatotic liver disease 94 samples shares liver
GSE303271 RNA-seq of liver biopsies from patients with pediatric autoimmune liver disease 64 samples shares liver

Search all human microarray datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.