GEO series

LNCAP/AR and a LnCAP/AR subline (LREX') with acquired resistance to 2nd generation antiandrogens

GSE51873 Homo sapiens Expression profiling by array 50 samples Submitted 2013/12/27 Platform GPL10558

Summary

The treatment of advanced prostate cancer has been transformed by novel antiandrogen therapies such as enzalutamide. Using the LnCaP/AR xenograft model, we identified induction of glucocorticoid receptor (GR) expression as a common feature of drug resistant tumors. From a resistant xenograft tumor, we derived a GR expressing resistant subline called LREX' which maintains the resistant phenotype. mRNA expression was used to characterize resistant tissues.

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Direct links to NCBI, no account and no request form: the whole study as GSE51873_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 50 samples.

Whole study · RAW.tar ↓ Series matrix ↓ All supplementary files ↗

Also filed as BioProject PRJNA225675. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗ Paper (PMID 24315100) ↗

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