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Geriatric muscle stem cells switch reversible quiescence into senescence (Set 4; Bmi1-deficient)

GSE53727 Mus musculus Expression profiling by array 9 samples Submitted 2013/12/31 Platform GPL13912
Summary
Regeneration of skeletal muscle depends on a population of adult stem cells (satellite cells) that remain quiescent throughout life. Satellite cell regenerative functions decline in geriatric satellite cells, compared to old cells are incapable of maintaining their normal quiescent state in muscle homeostatic conditions, and this irreversibly affects their intrinsic regenerative and self-renewal capacities. In geriatric mice, resting satellite cells lose reversible quiescence by switching to an irreversible pre-senescence state, caused by derepression of p16INK4a. Young Bmi1-deficient satellite cells shares similar features.
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Also filed as BioProject PRJNA232727. Searching any of these in the dataset finder brings you back here.

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