GEO series

Geriatric muscle stem cells switch reversible quiescence into senescence

GSE53728 Mus musculus (mouse) Expression microarray 36 samples Submitted 2013/12/31 Platform GPL13912

At a glance

Expression microarray · mouse · 36 samples

What it is: Expression microarrayGene activity read on a chip (the older technology that RNA-seq replaced).
Organism: Mus musculus (mouse)
Samples: 36 samples
Data you can get: A processed expression table (series matrix) and the array files, from NCBI.

Summary (written by the submitters)

Regeneration of skeletal muscle depends on a population of adult stem cells (satellite cells) that remain quiescent throughout life. Satellite cell regenerative functions decline with aging and in progeric conditions. Here we show that geriatric satellite cells, compared to old cells, are incapable of maintaining their normal quiescent state in muscle homeostatic conditions, and this irreversibly affects their intrinsic regenerative and self-renewal capacities.

This dataset

Open GSE53728 in finder → Find more mouse microarray datasets →

Download · which file do I need?

Direct links to NCBI, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.

1 · Just have a look

Processed table

The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.

Series matrix ↓

2 · Re-analyse it

Supplementary files

The count tables and other files the authors uploaded. Take only the samples you need.

All supplementary files ↗

3 · The original raw files

Whole study · RAW.tar

Everything the authors deposited as one archive (GSE53728_RAW.tar), including the raw array or instrument files. Can be large; the picker in step 2 takes just the samples you need.

Whole study · RAW.tar ↓

What the files usually look like: For arrays the series matrix is normally the normalised expression table you want; the raw array files (CEL and similar) are in the RAW.tar.

Also filed as BioProject PRJNA232724. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗ Paper (PMID 24522534) ↗

Samples in this study

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+ 36 more — browse all 36 samples with per-sample file links →

Datasets on a similar topic

GSE250460 Non-canonical roles of Keap1/Nrf2 in regulating quiescence and early activation in adult muscle stem cells 20 samples shares quiescence, muscle, stem
GSE250459 Non-canonical roles of Keap1/Nrf2 in regulating quiescence and early activation in adult muscle stem cells [RNA-Seq] 12 samples shares quiescence, muscle, stem
GSE55490 mTORC1 controls the systemically-induced adaptive regulation of stem cell quiescence into GAlert 21 samples shares quiescence, stem
GSE266096 Converged Epitranscriptomic Co-regulation of TGFβ Signaling Components Suppresses the Quiescence Transition of Early Postnatal Hippocampal Neural Stem Cells 33 samples shares quiescence, stem
GSE275974 SATB1 is a key regulator of quiescence in stem-like CD8+ T cells [RNA-seq] 10 samples shares quiescence, stem
GSE250278 Epigenetic maintenance of neural stem cell quiescence in the adult mouse hippocampus via Setd1a 51 samples shares quiescence, stem
GSE284224 Epitranscriptomic program promotes skeletal stem cell quiescence and pluripotency by regulating proteostasis via METTL3-FEM1B-GLI1 axis 44 samples shares quiescence, stem
GSE272195 Endothelial and systemic upregulation of miR-34a-5p fine-tunes senescence in progeria 36 samples shares senescence, stem

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