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Mismatch between mtDNA and nuclear DNA determines metabolism and healthy aging

GSE56933 Mus musculus Expression profiling by high throughput sequencing 24 samples Submitted 2016/07/13 Platform GPL11002
Summary
We postulate here that the two singular characteristics of the mitochondrial oxidative phosphorylation system—the integration of three potentially antagonistic functions in the same structure and the double genetic origin of the components that assemble together in these molecular machines—make the evolution of an optimal system impossible. As a consequence the system is intrinsically mismatched and has to be continuously monitored, Adjusted and regulated in order to achieve the necessary and variable performance. Systematic transcriptomic, Metabolomic and biochemical evaluation of animals with identical nuclear DNA but different mtDNA haplotype strongly support the existence of intrinsic mismatch and reveals profound lifelong metabolic consequences on reactive oxygen species generation, Insulin signaling, Tendency towards obesity, And healthy ageing parameters, Including telomere atresia
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Also filed as BioProject PRJNA245010 and SRA study SRP041313. Searching any of these in the dataset finder brings you back here.

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