GEO series

Regulation of gene expression by loss-of-YAP/TAZ in MCF10A mammary epithelial cells

GSE59229 Homo sapiens Expression profiling by array 12 samples Submitted 2015/03/23 Platform GPL570

Summary

YAP1 (Yes-associated protein 1) and TAZ (transcriptional coactivator with PDZ-binding motif, or WWTR1) are nucleo-cytoplasmic shuttling proteins that can function in the nucleus as transcriptional coactivators. Their role in regulating gene transcription has been so far mainly investigated by overexpressing YAP1 or TAZ, while here we sought to determine which genes are regulated by endogenous levels of YAP/TAZ. To this end, we compared MCF10A cells transfected with a control non-targeting siRNA to cells transfected with two independent mixes of siRNA targeting both YAP and TAZ.

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Direct links to NCBI, no account and no request form: the whole study as GSE59229_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 12 samples.

Whole study · RAW.tar ↓ Series matrix ↓ All supplementary files ↗

Also filed as BioProject PRJNA254775. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗ Paper (PMID 25796446) ↗

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