SRSF2 mutations impair hematopoiesis and alter exon recognition
RNA-seq (gene expression) · human · 14 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Topic
- Myelodysplastic syndromesThis series is part of our curated briefing on it.
- Samples
- 14 samples
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE65349_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA273749 and SRA study SRP052874. Searching any of these in the dataset finder brings you back here.
The sample list for this study is not cached yet. Press Load samples and it will be fetched from NCBI.
+ 14 more — browse all 14 samples with per-sample file links →
- GSE248296 Epigenetic vulnerabilities of leukemia harboring inactivating EZH2 mutations 24 samples same disease briefing · shares mutations
- GSE236535 Mutations in the splicing factor SF3B1 are linked to frequent emergence of HLA-DRlow/neg monocytes in lower-risk myelodysplastic neoplasms 9 samples same disease briefing · shares mutations
- GSE338788 Patient Derived Neomorphic SEPTIN6 Mutations Induce Hematopoietic Stem Cell Senescence Underlying Congenital Neutropenia and Myelodysplasia 8 samples same disease briefing · shares mutations
- GSE249209 Somatic Rescue and Cancer Mutations in Telomere Biology Disorders 7 samples same disease briefing · shares mutations
- GSE256396 Somatic mutations and DNA methylation identify a subgroup of poor prognosis within lower risk myelodysplastic syndromes 374 samples same disease briefing · shares mutations
- GSE15688 Acquired mutations in TET2 are common in myelodysplastic syndromes 122 samples same disease briefing · shares mutations
- GSE289476 Natural killer cells’ functional impairment drives the immune escape of pre-malignant clones in early-stage myelodysplastic syndromes 16 samples same disease briefing · shares impair
- GSE282251 Multiclonal competition reveals impaired cell fitness of GATA2 deficient cells [ATAC-seq] 6 samples same disease briefing · shares impair
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.