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Single Cell triple omics sequencing reveals genetic and epigenetic heterogeneity in hepatocellular carcinoma

GSE65364 Homo sapiens; Mus musculus Expression profiling by high throughput sequencing; Methylation profiling by high throughput sequencing 95 samples Submitted 2016/03/01 Platform GPL17021Platform GPL11154Platform GPL20795Platform GPL16791
Summary
Single cell genome, DNA methylome, and transcriptome sequencing has been achieved separately. However, to analyze the regulation of RNA expression by genetic and epigenetic factors within an individual cell, it is necessary to analyze these omics simultaneously from the same single cell. Here we developed a single cell triple omics sequencing technique- scTrio-seq, to analyze the genome, DNA methylome, and transcriptome concurrently of a mammalian cell.
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Also filed as BioProject PRJNA273802 and SRA study SRP052901. Searching any of these in the dataset finder brings you back here.

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