The Small Molecule ISRIB Reverses the Effects of eIF2α Phosphorylation on Translation and Stress Granule Assembly
RNA-seq (gene expression) · human · 16 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 16 samples
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE65778_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA274997 and SRA study SRP053402. Searching any of these in the dataset finder brings you back here.
The sample list for this study is not cached yet. Press Load samples and it will be fetched from NCBI.
+ 16 more — browse all 16 samples with per-sample file links →
- GSE323995 CReP-mediated control of eIF2a phosphorylation is a central node in high-risk medulloblastoma [RNA-Seq 3] 48 samples shares eif2, phosphorylation
- GSE290626 CReP-mediated control of eIF2a phosphorylation is a central node in high-risk medulloblastoma [D458] 24 samples shares eif2, phosphorylation
- GSE290496 CReP-mediated control of eIF2a phosphorylation is a central node in high-risk medulloblastoma. 9 samples shares eif2, phosphorylation
- GSE282509 Human eIF2A has a minimal role in translation initiation and in uORFmediated translational control 20 samples shares eif2, translation
- GSE256237 The G3BP Stress-Granule Proteins Reinforce the Translation Program of the Integrated Stress Response 68 samples shares translation, granule
- GSE307666 eIF3d and eIF3e mediate selective translational control of hypoxia that can be inhibited by small molecules 120 samples shares translation, molecule
- GSE287132 DNA binding and mitotic phosphorylation protect polyglutamine proteins from assembly formation 18 samples shares phosphorylation, assembly
- GSE260934 Coordination between the eIF2 kinase GCN2 and p53 signaling supports purine metabolism and the progression of prostate cancer 16 samples shares eif2
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.