Widespread association between YAP/TAZ/TEAD and AP-1 at enhancers drives oncogenic growth
ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 25 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Homo sapiens (human)
- Samples
- 25 samples: 25 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed expression table (series matrix) and the array files, from NCBI.
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE66083_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA275842 and SRA study SRP055170. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 25 sample titles: 25 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM1614028 YAP_rep1_ChIPSeq
- GSM1614029 YAP_rep2_ChIPSeq
- GSM1614030 TAZ_rep1_ChIPSeq
- GSM1614031 TAZ_rep2_ChIPSeq
- GSM1614032 IgG_rep1_ChIPSeq
- GSM1614033 IgG_rep2_ChIPSeq
- GSM1614034 TEAD4_rep1_ChIPSeq
- GSM1614035 TEAD4_rep2_ChIPSeq
- GSM1614036 JUN_rep1_ChIPSeq
- GSM1614037 JUN_rep2_ChIPSeq
- GSM1614038 IgG_rep3_ChIPSeq
- GSM1614039 IgG_rep4_ChIPSeq
- GSM1614040 IgG_rep5_ChIPSeq
- GSM1614041 MDA-MB-231 cells siControl, biological replica A
- GSM1614042 MDA-MB-231 cells siControl, biological replica B
- GSM1614043 MDA-MB-231 cells siControl, biological replica C
- GSM1614044 MDA-MB-231 cells siControl, biological replica D
- GSM1614045 MDA-MB-231 cells siYAP/TAZ#1, biological replica A
- GSM1614046 MDA-MB-231 cells siYAP/TAZ#1, biological replica B
- GSM1614047 MDA-MB-231 cells siYAP/TAZ#1, biological replica C
- GSM1614048 MDA-MB-231 cells siYAP/TAZ#1, biological replica D
- GSM1614049 MDA-MB-231 cells siYAP/TAZ#2, biological replica A
- GSM1614050 MDA-MB-231 cells siYAP/TAZ#2, biological replica B
- GSM1614051 MDA-MB-231 cells siYAP/TAZ#2, biological replica C
- GSM1614052 MDA-MB-231 cells siYAP/TAZ#2, biological replica D
- GSE66082 Widespread association between YAP/TAZ/TEAD and AP-1 at enhancers drives oncogenic growth [gene expression] 12 samples shares tead, ap-1, yap, taz, widespread, enhancers, oncogenic, drives
- GSE295183 HIF2ɑ Requires Engagement with YAP/TAZ and AP-1 Transcription Factors to Maintain Oncogenic Transcription in Clear Cell Renal Cell Carcinoma [CUT&Tag] 60 samples shares ap-1, yap, taz, oncogenic
- GSE208717 Adenovirus small E1A directs activation of Alu transcription at YAP/TEAD- and AP-1- bound enhancers through interactions with the EP400 chromatin remodeler 28 samples shares tead, ap-1, yap, enhancers
- GSE208716 Adenovirus small E1A directs activation of Alu transcription at YAP/TEAD- and AP-1- bound enhancers through interactions with the EP400 chromatin remodeler [RNA-Seq] 16 samples shares tead, ap-1, yap, enhancers
- GSE208685 Adenovirus small E1A directs activation of Alu transcription at YAP/TEAD- and AP-1- bound enhancers through interactions with the EP400 chromatin remodeler [ChIP-Seq] 12 samples shares tead, ap-1, yap, enhancers
- GSE330470 ChIP-seq and CUT&Tag profiling of the genome binding of YAP/TAZ-TEAD and SMAD3 in the human HCC cell line HCCLM3 [ChIP-seq] 55 samples shares tead, yap, taz
- GSE275987 YAP/TAZ cooperate with AP-1 to drive the mesenchymal cell state in neuroblastoma [CnR] 42 samples shares ap-1, yap, taz
- GSE275995 YAP/TAZ cooperate with AP-1 to drive the mesenchymal cell state in neuroblastoma [RNAseq] 36 samples shares ap-1, yap, taz
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.