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Achilles Heels of Senescent Cells: From Transcriptome to Senolytic Drugs

GSE66236 Homo sapiens Expression profiling by array 16 samples Submitted 2015/03/10 Platform GPL17244
Summary
The healthspan of mice is enhanced by selectively killing senescent cells using a transgenic suicide gene. Achieving the same using small molecules would have a tremendous impact on quality of life and burden of age-related chronic diseases. As senescent cells resist apoptosis, we used microarrays to identify transcripts and pathways that differ between senescent and non-senescent preadipocytes, and might be involved in resistance to apoptosis.
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Also filed as BioProject PRJNA276172. Searching any of these in the dataset finder brings you back here.

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