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CMV infection drives adaptive epigenetic diversification of NK cells

GSE66562 Homo sapiens Methylation profiling by genome tiling array 23 samples Submitted 2015/03/06 Platform GPL13534
Summary
The mechanisms underlying human NK cell phenotypic and functional heterogeneity are unknown. Here, we describe the emergence of diverse subsets of human NK cells selectively lacking expression of signaling proteins following cytomegalovirus (CMV) infection. The absence of B and myeloid cell-related signaling protein expression in these NK cell subsets correlated with promoter DNA hypermethylation. Intriguingly, geneome-wide analyses revealed patterns of DNA methylation that were strikingly similar between CMV-associated adaptive NK cells and cytotoxic effector CD8+ T cells, but differed from those of canonical NK cells.
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Also filed as BioProject PRJNA277345. Searching any of these in the dataset finder brings you back here.

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