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caArray_gray-00215: A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes

GSE69017 Homo sapiens Expression profiling by array 51 samples Submitted 2015/05/19 Platform GPL96
Summary
Recent studies suggest that thousands of genes may contribute to breast cancer pathophysiologies when deregulated by genomic or epigenomic events. Here, we describe a model system to appraise the functional contributions of these genes to breast cancer subsets. In general, the recurrent genomic and transcriptional characteristics of 51 breast cancer cell lines mirror those of 145 primary breast tumors, although some significant differences are documented. The cell lines that comprise the system also exhibit the substantial genomic, transcriptional, and biological heterogeneity found in primary tumors. We show, using Trastuzumab (Herceptin) monotherapy as an example, that the system can be used to identify molecular features that predict or indicate response to targeted therapies or other physiological perturbations. **NOTE: Migrated from caArray 1.x, identifier='gov.nih.nci.ncicb.caarray:Experiment:1015897590151581:1'
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Also filed as BioProject PRJNA284295. Searching any of these in the dataset finder brings you back here.

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