GEO series

Gene expression data from ATRT tumor samples

GSE70678 Homo sapiens Expression profiling by array 49 samples Submitted 2016/03/02 Platform GPL570

Summary

Atypical teratoid/rhabdoid tumor (ATRT) is one of the most common brain tumors in infants. Although the prognosis of ATRT patients is poor, some patients respond favorably to current treatments, suggesting molecular inter-tumor heterogeneity. To investigate this further, we genetically and epigenetically analyzed a large series of human ATRTs. Three distinct molecular subgroups of ATRTs, associated with differences in demographics, tumor location, and type of SMARCB1 alterations, were identified. Whole-genome DNA and RNA sequencing found no recurrent mutations in addition to SMARCB1 that would explain the differences between subgroups. Whole-genome bisulfite sequencing and H3K27Ac chromatin-immunoprecipitation sequencing of primary tumors, however, revealed clear differences, leading to the identification of subgroup-specific regulatory networks and potential therapeutic targets.

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Direct links to NCBI, no account and no request form: the whole study as GSE70678_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 49 samples.

Whole study · RAW.tar ↓ Series matrix ↓ All supplementary files ↗

Also filed as BioProject PRJNA289342. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗ Paper (PMID 26923874) ↗

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