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Generation of Stem Cell-Derived β Cells from Type 1 Diabetic Patients

GSE70901 Homo sapiens Expression profiling by array 16 samples Submitted 2016/04/01 Platform GPL10558
Summary
We recently reported the scalable in vitro production of functional stem cell-derived β cells. Here we extend this approach to generate SC-β cells from Type 1 diabetic patients (T1D), a cell type that is destroyed during disease progression and has not been possible to extensively study. These cells express β cell markers, respond to glucose both in vitro and in vivo, prevent alloxan-induced diabetes in mice, and respond to anti-diabetic drugs. Furthermore, we use an in vitro disease model to demonstrate the cells respond to different forms of β cell stress. Using these assays, we find no major differences in T1D SC-β cells compared to SC-β cells derived from non-diabetic patients (ND). These results show that T1D SC-β cells can be used for the treatment of diabetes, drug screening, and the study of β cell biology.
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Also filed as BioProject PRJNA289894. Searching any of these in the dataset finder brings you back here.

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