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Bone marrow-derived monocytes give rise to self-renewing and fully differentiated Kupffer cells

GSE75225 Mus musculus Expression profiling by array 19 samples Submitted 2015/11/21 Platform GPL6246

Summary

Self-renewing tissue-resident macrophages are thought to be exclusively derived from embryonic progenitors. However, whether circulating monocytes can also give rise to such macrophages has not been formally investigated. Here we use a new model of diphtheria toxin-mediated depletion of liver-resident Kupffer cells to generate niche availability and show that circulating monocytes engrafted in the liver, gradually adopt the transcriptional profile of their depleted counterparts and become long-lived self-renewing cells. Underlining the physiological relevance of our findings, circulating monocytes also contribute to the expanding pool of macrophages in the liver shortly after birth, when macrophage niches become available during normal organ growth. Thus, like embryonic precursors, monocytes can and do give rise to self-renewing tissue-resident macrophages if the niche is available to them.

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Direct links to NCBI, no account and no request form: the whole study as GSE75225_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 19 samples.

Whole study · RAW.tar ↓ Series matrix ↓ All supplementary files ↗

Also filed as BioProject PRJNA302849. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗ Paper (PMID 26813785) ↗

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