GEO series

Differentiation of human and murine induced pluripotent stem cells to microglia-like cells [human]

GSE78115 Homo sapiens Expression profiling by array 21 samples Submitted 2017/03/02 Platform GPL16686

Summary

Microglia are myeloid-lineage inflammatory cells that activate innate and adaptive immune responses within the central nervous system (CNS). They also have important roles in CNS development and homeostasis and can modulate the course of a variety of CNS diseases. We report here the sequential differentiation of murine induced pluripotent stem cells (iPSC) into hematopoietic progenitor-like cells and then into cells with a phenotype and gene expression profile resembling that of primary brain-isolated microglia. Functionally, the iPSC-derived microglia (iPS-MG) produce inflammatory cytokines and reactive oxygen species, demonstrate phagocytic activity and migrate to areas of pathology within the brain following intracranial injection. The ability to readily generate iPS-MG in vitro will facilitate the study of normal and disease-specific microglia and be useful for the development of microglia-based treatments for CNS diseases.

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Direct links to NCBI, no account and no request form: the whole study as GSE78115_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 21 samples.

Whole study · RAW.tar ↓ Series matrix ↓ All supplementary files ↗

Also filed as BioProject PRJNA312652. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗ Paper (PMID 28253233) ↗

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