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A long noncoding RNA lincRNA-EPS acts as a transcriptional brake to restrain inflammation

GSE78873 Mus musculus Other 12 samples Submitted 2016/05/08 Platform GPL19057
Summary
LincRNA-EPS is a long noncoding RNA that is expressed in macrophages and downregulated upon exposure to diverse microbial products. Analysis of macrophages from lincRNA-EPS-deficient mice revealed a specific role for this lincRNA in restraining immune response gene (IRG) expression. Mechanistically, lincRNA-EPS associates with chromatin at regulatory regions of IRGs to repress their transcription. To gain insight into the molecular function of lincRNA-EPS on chromatin, we generated ATAC-Seq libraries from wildtype and lincRNA-EPS-deficient macrophages stimulated with LPS.
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Also filed as BioProject PRJNA314247 and SRA study SRP071137. Searching any of these in the dataset finder brings you back here.

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